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Terrorism
Prepareness
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DIRECTORY
GLOBAL WAR ON TERRORISM
INFORMATION RESOURCES
OPERATION ENDURING FREEDOM OPERATION IRAQI FREEDOM
CHRONOLOGY OF TERRORIST ATTACKS
AGAINST AMERICA 1961 - 1996
CHRONOLOGY OF TERRORIST ATTACKS
AGAINST AMERICA 1997 - 2001
HOMELAND SECURITY NEWS
HUMOROUS CARTOONS AND JOKES TERRORISM PREPAREDNESS GUIDE OSAMA BIN LADIN BIOGRAPHY

TERRORISM FAQ
What to do with a suspicious letter or parcel
Before The Attack
Emergency Supply Kit List
During The Attack
After The Attack
What Should You Do?
Coping With Terrorism
Coping Strategies
Children's Reactions


by Sgt. William A. Graves
WASHINGTON (Army News Service, October 24, 2002)
Many national and senior Army leaders have said it's not 
a question if terrorists will strike again; it's a matter 
of when and where. "We want to be a nation that serves 
goals larger than self," said President George W. Bush 
during the State of the Union Address. "We have been 
offered a unique opportunity, and we must not let this 
moment pass." "We are all combatants," Maj. Gen. Paul 
Eaton recently said. Given that, residents of Army posts 
across the country, along with civilians, can benefit from 
learning what to do to help prevent and prepare for 
terrorist attacks, according to the Citizencorps Web site, 
Alice Bass, directorate of Intelligence and Security, 
offered advice on preventing terrorist attacks:
o Be alert to strangers on government property for 
no apparent reason.

o Write down license numbers of suspicious vehicles, 
noting the description of the occupants.

o Report anything unusual to your chain of command; 
report unusual or suspicious behavior.

o Avoid using your name and rank on answering machines.

o Don't open your door to strangers; use a peephole viewer.

o Ask for identification for contractors assigned to work 
on your home and quarters.

o Brief family members on residential security and safety 
procedures.

o Instruct family not to provide strangers with information 
about you or your family.

People should do the following to do their part 
in the prevention of terrorist attacks:

o Know your routines.  Be alert as you go about your 
daily business.  This will help you learn the normal 
routines of your neighborhood, community and work place.  
Understanding these routines will help you to spot 
anything out of place.

o Be aware.  Get to know your neighbors at home and 
while traveling.  Be on the lookout for activities such 
as unusual conduct in your neighborhood or in your 
workplace.  Learn to spot suspicious packages, luggage 
or mail abandoned in a crowded place like an office 
building, an airport, a school or a shopping center.

o Take what you hear seriously.  If you hear or know of 
someone who has bragged or talked about plans to harm 
citizens in violent attacks or who claims membership in 
a terrorist organization, take it seriously and report 
it to law enforcement immediately

People can do much more to help with the war on terrorism, 
Eaton said.  People should lose weight if necessary, know 
how to fire a weapon accurately and be able to administer 
first aid, he advised.

According to the Citizencorps Web site, the Citizen Corps 
has many opportunities for people who want to volunteer 
their time or be proactive in the fight against terrorism.  

Volunteer opportunities include:

o Citizen Corps Councils, which help drive local citizen 
participation by coordinating Citizen Corps programs, 
developing community action plans, assessing possible 
threats and identifying local resources.

o The Community Emergency Response Team, which is a 
training program that prepares people in neighborhoods, 
the workplace, and schools to take a more active role in 
emergency management planning, and to prepare themselves 
and others for disasters.

o An expanded Neighborhood Watch Program, which incorporates 
terrorism prevention and education into its existing crime 
prevention mission.

o Volunteers in Police Service, who provide support for 
resource-constrained police departments by using civilian 
volunteers to free up more law enforcement professionals 
for frontline duty.

o The Medical Reserve Corps, which coordinates volunteer 
health professionals during large-scale emergencies to assist 
emergency response teams, provide care to victims with less 
serious injuries, and remove other burdens that inhibit the 
effectiveness of physicians and nurses in a major crisis.

o Operation TIPS, Terrorism Information and Prevention System, 
which is a nationwide program providing millions of workers who, 
by the nature of their jobs, are well-positioned to recognize 
unusual events with a formalized way to report suspicious 
activity to the nearest FBI field office.

What can people do to prepare for a possible attack? 
According to the  Red Cross Web site,  
you should:

o Create an emergency communications plan. 
Choose an out-of-town contact your family or household will 
call or e-mail to check on each other should a disaster occur.

o Establish a meeting place.

o Having a predetermined meeting place away from your home 
will save time and minimize confusion should your home be 
affected or the area evacuated. Be sure to include any pets 
in these plans, since pets are not permitted in shelters, and 
some hotels will not accept them.

o Assemble a disaster supplies kit. If you need to evacuate 
your home or are asked to shelter "in place," having some 
essential supplies on hand will make you and your family more 
comfortable.

o Check on the school emergency plan of any school-age children 
you have. Administrators may keep children at school until a 
parent or designated adult can pick them up or send them home 
on their own. The schools should have updated information about 
how to reach parents and responsible caregivers to arrange for 
pickup.  If people are unable to pick up their child, schools 
require proper identification to release a child to someone you 
designate.

(Editor's Note: Sgt. William A. Graves is the assistant editor 
for the Fort Benning, Ga. Bayonet Newspaper).



Before an Attack

Learn about the nature of terrorism Terrorists look for visible targets where they can avoid detection before or after an attack, such as international airports, large cities, major international events, resorts and high-profile landmarks. Adapt, as appropriate, the same techniques used to prepare for earthquakes, fires and other emergencies. Be prepared and observe your environment. Terrorists most often strike with little or no warning. Use caution when you travel. Observe and report unusual activity. Keep your packages with you at all times. Do not accept packages from strangers. Locate stairways and emergency exits and develop plans for evacuating buildings and crowded public areas. If you live or work in multi-level buildings: Identify the location of fire exits and review emergency evacuation procedures. Locate and maintain fire extinguishers in working order and learn how to use them. Obtain training in first aid and CPR. Assemble and maintain an emergency supply kit in back packs to keep in your home and car.

Emergency Supply Kit

Maintaining an emergency supply kit is a good idea for any emergency. Individuals and organizations should be prepared to be without assistance for a minimum of 72 hours.
  • WATER
  • Food (canned, no-cook, packaged snacks)
  • Manual can opener
  • Battery-powered radio, flashlights, batteries
  • Whistle
  • First aid kit and manual
  • Essential medicines and eyeglasses
  • Fire extinguisher (A-B-C) type
  • Hard hats
  • Duct tape
  • Cash and credit cards
  • Change of clothing, rain gear, and sturdy shoes
  • Blankets or sleeping bags
  • Infant and feminine hygiene supplies
  • Fire extinguisher (A-B-C) type
  • Names, addresses, and telephone numbers of doctors and pharmacists
  • Food and water for pets
  • Large plastic bags for trash, waste, water protection
  • Toilet paper and paper towels
  • Charcoal grill or camp stove for outdoor cooking
  • Fluorescent tape to rope off dangerous areas

During an Attack

If there’s an explosion:
  • Remain calm. Take cover under a desk or sturdy table if ceiling tiles, bookshelves, their contents, etc. begin to fall.
  • Exit the building as quickly as possible.
If there’s a fire:
  • Stay low to the floor at all times and exit the building as quickly as possible. Heavy smoke and poisonous gases collect near the ceiling first.
  • Use a wet cloth to cover your nose and mouth.
  • Use the back of your hand to feel closed doors. If the door is not hot, brace yourself against the door and open it slowly. Do not open the door if it is hot. Seek another escape route.
  • Use appropriate fire exits, not elevators.

After an Attack

If you are trapped in debris:
  • If possible, use a flashlight or whistle to signal rescuers regarding your location.
  • Stay in your area so that you don’t kick up dust.
  • Cover your mouth with a handkerchief or clothing.
  • Tap on a pipe or wall so that rescuers can hear where you are.
  • Shout only as a last resort shouting can cause a person to inhale dangerous amounts of dust.
Protective Actions Protective actions are actions we take to safeguard our family members and ourselves from harm. The most common emergency protective actions are evacuation and shelter-in-place. Evacuation means to leave the area of actual or potential hazard. Shelter-in-place means to stay indoors. This includes additional precautions such as turning off air- conditioning, ventilation systems and closing all windows and doors.

What Should You Do?

  • Remain calm.
  • Be aware of your surroundings.
  • HAVE A FAMILY PREPARENESS PLAN.
  • Stay informed.
If an evacuation is ordered, follow the instructions of local officials regarding evacuation routes and the location of shelters. If shelter-in-place is recommended, local officials will provide instructions on necessary actions. Do not leave your sheltered location or return to the evacuated area until it is deemed safe to do so by local officials.

Coping With Terrorism

First, keep in mind that the goal of terrorism is to fill people with intense fear, to intimidate people to deliver a political message, and to paralyze government and commerce. Americans have power over how we respond to these events, and our nation is choosing to respond with dignity, community, heroism, and patriotism. The terrorist events of September 11, 2001 have evoked strong and deep reactions in both adults and children. It is important for people to realize that their reactions are normal in these very abnormal and tragic circumstances, and to know that there are things people can do to cope and to help each other through these difficult times. Common reactions include shock, disbelief, disorientation, fear, worry about safety, concern about loved ones, and grief. After the initial shock wears off, people may have mood swings, crying, jumpiness, irritability, fatigue, feeling overwhelmed, trouble concentrating, difficulty sleeping, nightmares, and feeling numb or not particularly upset. These are normal reactions. Sometimes people seem to shut down for a while after a disaster. Children are affected by what they see and hear on television, and by how their parents react. Common reactions in children include asking questions about what happened and why, fear for safety, not wanting to be separated from family, regression to behaviors from a younger age, fear of sleeping alone, headaches and stomachaches, and a decline in school performance.

Coping Strategies

The following are some suggestions for dealing with the psychological and emotional impact of these terrorist events:
  • Try to understand at least the principal details about what happened and evaluate the chances that it could happen again.
  • Gather facts before reacting.
  • Try to maintain a normal routine. Unless public safety officials have issued warnings or closed buildings, continue in your normal daily activities. Remember that the goal of terrorism is to make you fearful. Rather than being intimidated, follow the advice of professional public safety officials.
  • Follow your usual routine of physical activity and exercise. Eat well and try to get rest, even if your sleep is not as restful as usual.
  • Avoid self-medication such as alcohol, caffeine, or other drugs.
  • Draw on known sources of comfort that have sustained you and helped you in difficult times in the past.
  • Share your concerns and worries by talking with a friend, family member, or clergy. Reach out to each other while taking care of yourself.
  • If you wish to participate in community recovery activities, volunteer or donate to a known disaster response agency with a clear mission. Spontaneous, unorganized volunteers at a disaster site only add to the confusion.
  • Children's Reactions

    You can assist your children with some of the following suggestions:
    • Spend more time with them and be comfortable with their temporarily slipping back into behaviors from an earlier age.
    • Talk with them about what has happened and do your best to answer their questions. No one can totally answer the question of "why" this has happened or why people do "bad" things. Help them to be aware of the positive response of people to the disaster-of the people all over the world who are responding to the crisis in a helpful way.
    • Your children may be fearful about the safety of buildings or airplanes. Remind them that what happened is a very rare event, and not something that happens every day. Security at buildings and airports is higher than ever. Do everything possible to reasonably reassure your children about safety.
    • Reassure your children that you care about them, that you understand their feelings and concerns, and that you are there for them. Physical affection is comforting, especially to young children.
    • Try to limit the amount of television coverage both you and your children watch, especially children under the age of four. We know clearly from past disasters that media images can traumatize people, especially children. Encourage them to talk with you about their thoughts and feelings about what they have seen. Consider having them draw pictures, or for older children, write in their journal about some of their feelings.
    • Try to keep a regular schedule of activities such as eating, playing, studying, and going to bed to help restore a sense of security and normalcy. Emotions and problems with concentrating may interfere with studying for awhile.
    • Talk to your children’s teachers, day-care providers, and babysitters about your child’s response to the event and about what they doing to assist children.
    • While children may be angry about what happened, caution them not to speak or act with prejudice against people of ethnic or religious groups that they think may have been involved. Justice for the people who made the attack must be done with dignity and within the structure of the law.
    • Teenagers may want to volunteer or donate to community recovery activities and should be encouraged to do so.
    • If you find that your reactions to the terrorist events of September 11 are disrupting your daily functions, such as job performance or relationships, it may be helpful to attend a community support group or debriefing group, or to talk with a mental health professional. For children, prolonged or extreme withdrawal, emotional outbursts, serious problems at school, or other signs of intense anxiety or emotion are signs that it may be helpful to talk to a mental health professional. Contact your local mental health agency for assistance.

      TERRORISM FAQ

      1. What is anthrax? Anthrax is a disease caused by bacteria called Bacillus anthracis. The form of the disease that health authorities are concerned that a bioterrorist attack might produce is inhalational anthrax. Inhalational anthrax occurs when a person breathes in anthrax spores. As early as a day or two after exposure or as late as seven weeks afterward, the spores begin to grow rapidly and the victim develops fever, has difficulty breathing and feels miserable. Death typically occurs within a few days after these symptoms if the person doesn't receive medical treatment. It is believed that antibiotics can stop the disease if they are taken at the time the anthrax spores begin to grow or very soon thereafter. In the event of a bioterrorist attack, health authorities would conduct a rapid investigation, determine the place and time of the release, and identify individuals who need antibiotics. The federal government has stockpiled antibiotics for large-scale distribution in the event of a bioterrorist attack. 2. Is anthrax contagious? Anthrax is not contagious between people. Healthy people who come into contact with persons sick with anthrax cannot acquire the disease. Anthrax can be transmitted through contact with infected animal products. 3. How dangerous is skin (cutaneous) anthrax? Not very, if treated promptly. Anthrax can enter the skin through a cut or abrasion, but it rarely enters the bloodstream through this route. After infection, the area swells up, may get blisters, and turns into a dark brown or black scab, which falls off in one to two weeks. This form of anthrax has been common in animal handlers in less developed areas of the world. Although skin anthrax can sometimes clear up without treatment, antibiotics are highly effective and easily available. Remember, soap and water are the first line of defense against germs on the skin. 4. Should I buy antibiotics just in case? No. There are a number of different germs a bioterrorist might use to carry out an attack. Many antibiotics are effective for a variety of diseases, but there is no antibiotic that is effective against all diseases. Thus, no single pill can protect against all types of biological weapon attacks. Keeping a supply of antibiotics on hand poses other problems because the antibiotics have a limited "shelf life" before they lose their strength. There is currently no justification for taking antibiotics without a confirmed exposure to a specific organism, which that antibiotic would be effective against. Also, it should be known that antibiotics can cause side effects. They should only be taken with medical supervision. 5. Should I buy a gas mask? No. A mask would only protect you if you were wearing it at the exact moment a bioterrorist attack occurred. Unfortunately, a release of a biological agent is most likely to be done "covertly," that is, without anyone knowing it. That means you would not know ahead of time to put on your mask. To wear a mask continuously or "just in case" a bioterrorist attack occurs, is impractical, if not impossible. To work effectively, masks must be specially fitted to the wearer, and wearers must be trained in their use. This is usually done for the military and for workers in industries and laboratories who face routine exposure to chemicals and germs on the job. Gas masks purchased at an Army surplus store or off the internet carry no guarantees that they will work. In fact, one national chain of surplus stores provides the following statement: "(X) has been selling gas masks as a novelty item since 1948. We have never been able to warrant their effectiveness and we cannot do so at this time...We do not know what each type of gas mask we sell might or might not be effective against...We do not know the age of each gas mask" In brief, no guarantees whatsoever are provided. More serious is the fact that the masks can be dangerous. There are reports of accidental suffocation when people have worn masks incorrectly, as happened to some Israeli civilians during the Persian Gulf War. 6. Is it safe for me to drink water from the tap? Yes. It would be extremely difficult for a bioterrorist to contaminate our drinking water supplies to cause widespread illness. There are two reasons. First of all, huge amounts of water are pumped daily from our reservoirs, most of which is used for industrial and other purposes; very little is actually consumed. Thus, anything deliberately put into the water supply would be greatly diluted. Secondly, water treatment facilities routinely filter the water supply and add chlorine in order to kill harmful germs. 7. What is smallpox? Smallpox is a disease caused by the Variola virus. Historically, 1 out of 3 people who contracted the disease died. The disease can spread from person to person. Transmission usually occurs only after the patient develops a fever and rash. Although there is no treatment for the disease, a vaccine against smallpox provides excellent protection and serves to stop the spread of the disease. While many vaccines must be given weeks or months before a person is exposed to infection, smallpox vaccine is different. It protects a person even when given 2 to 3 days after exposure to the disease and may prevent a fatal outcome even when given as late as 4 to 5 days after exposure. Smallpox was stamped out globally by 1980 and vaccination stopped everywhere in the world. However, the Centers for Disease Control and Prevention (CDC) maintain an emergency supply of smallpox vaccine. Currently there are 12-15 million doses in storage, and a program to produce more vaccine began a year ago. 8. If smallpox is a potential threat to the U.S., why shouldn't we all get vaccinated? The vaccine may cause serious side effects. In 1972, the U.S. decided to stop routinely vaccinating its citizens because many people were experiencing side effects, while they had almost no risk of getting smallpox. By 1972, the disease was present only in a few countries of Asia and Africa. Today, health authorities would only recommend vaccination if there was clear evidence that the disease had resurfaced and those in the U.S. were at risk of acquiring infection.Many people over age 30 have a vaccination scar. Vaccination consists of introducing the virus into the top layers of the skin. Over the following few days, a blister forms at the site of vaccination (usually the upper arm). The arm is sore, and there is fever. Very rarely, some people get a vaccine- related infection of the brain (about 1 case per 300,000 vaccinations); one fourth of these cases are fatal. Other potential negative effects of the vaccine are a severe skin reaction, spread of the vaccine virus (known as Vaccinia) to other parts of the body, and spread of the Vaccinia virus to other people. 9. If I was vaccinated against smallpox before 1980, am I still protected? Probably not. Vaccination has been shown to wear off in most people after 10 years but may last longer if the person has been successfully vaccinated on multiple occasions. If health authorities determine that you have been exposed to smallpox or are at risk of infection, they would recommend that you be re-vaccinated immediately. 10. What is the National Pharmaceutical Stockpile (NPS)? The NPS is a large reserve of antibiotics, chemical antidotes and other medical supplies set aside for emergencies. The CDC reports that it has the capacity to move these stockpiled materials to affected areas in the U.S. within 12 hours of notification. There are a number of different stockpiles, strategically located around the country. In addition to the medical supplies already set aside, the federal government has made agreements with drug manufacturers to make large amounts of additional emergency medicine. For more information on the NPS. 11. What if my fear about bioterrorism is having a serious impact on my family and work life? Given the attacks upon civilians that took place on September 11, it is reasonable for citizens to feel anxious about their personal safety. Should your fear get to the point that it stops you from doing the things you would normally do in a day, it might be helpful to talk with someone. Your health care provider can make a referral if you do not already have someone in mind. In the wake of the attack on New York City, we have learned how helpful it has been to many New Yorkers to speak with a counselor or to go to a mental health center. The information below describes how to identify a suspicious mail piece and the procedures to follow: 12. What constitutes a suspicious letter or parcel? Some typical characteristics which ought to trigger suspicion include letters or parcels that:
      • Have any powdery substance on the outside.
      • Are unexpected or from someone unfamiliar to you.
      • Have excessive postage, handwritten or poorly typed address, incorrect titles or titles with no name, or misspellings of common words.
      • Are addressed to someone no longer with your organization or are otherwise outdated.
      • Have no return address, or have one that can't be verified as legitimate.
      • Are of unusual weight, given their size, or are lopsided or oddly shaped.
      • Have an unusual amount of tape.
      • Are marked with restrictive endorsements, such as "Personal" or "Confidential."
      • Have strange odors or stains.
      13. What Should I do if I Receive an Anthrax Threat by Mail?
      • Do not handle the mail piece or package suspected of contamination.
      • Make sure that damaged or suspicious packages are isolated and the immediate area cordoned off.
      • Ensure that all persons who have touched the mail piece wash their hands with soap and water.
      • Notify your local law enforcement authorities.
      • List all persons who have touched the letter and/or envelope.
      • Include contact information and have this information available for the authorities.
      • Place all items worn when in contact with the suspected mail piece in plastic bags and have them available for law enforcement agents.
      • As soon as practical, shower with soap and water.
      • Notify the Center for Disease Control Emergency Response at 770-488-7100 for answers to any questions.
      BIOTERRORISM RESPONSE by Meryl Nass, MD Issues that need to be addressed regarding the bioterrorism response include the following: 1.Are the anthrax-containing envelopes an initial tease, or warning? They are a good way to disseminate small quantities, while avoiding identification of the sender. But what may be ahead? Spores in ventilation systems? Spores at sports events or where there are dense population concentrations? Thousands or millions of letters containing anthrax? How will we know in time, and how will we decontaminate ventilation systems, electronics, sports arenas, soil, etc.? 2.At the present time, public health authorities have continued to use (primarily cutaneous) human anthrax cases as the harbingers of anthrax dissemination. Cutaneous infections require many fewer spores to induce illness, compared to inhalation anthrax. The infected individuals are serving as the "canaries in the mineshaft" who warn that anthrax is present. If the extent of spore dissemination increases (higher concentrations in ambient air from envelopes, or through other means) then the inhalation cases will serve as the canaries, and there will be many fatalities. 3. will continue to harp on the need for accurate and rapid sampling of the environment as the most important (by far) technology needed to deal with the offensive use of anthrax. There are likely to be many more envelopes that have already dispersed anthrax spores, but have not been identified yet, because there have (so far) been no cases of illness related to those envelopes, and spores were not seen by the person(s) handling the mail. This means that anthrax spores may be contaminating a number of environments in which they have not been detected. We may not see cases until small animals, children, or people with immune system impairment become exposed in those environments. 4.Only by identifying an environment contaminated with anthrax before illness appears are we likely to effectively treat inhalation cases. 5.Only by identifying these environments can we remove people from the environment and protect them from further exposure. 6.It is possible that we will not be able to do a complete clean up of contaminated environments, for the time being. There has not been a great deal of research into how to clean up homes and offices, for example. Gruinard Island, off the coast of Scotland, was decontaminated 45 years after it was used as a test area for anthrax during World War II. During those 45 years, humans and animals were barred from the island. Ten acres were decontaminated: this required defoliating the area, using 200 tons of 37% formaldehyde, diluted in seawater, that was sprayed over the area, and then additional formaldehyde was re-sprayed after deep soil sampling revealed persistent organisms. 7.What else works to kill anthrax spores, which can remain viable for decades or hundreds or years? Bleach, which must be in contact with spores for at least 2 minutes. Paraformaldehyde gas, glutaraldehyde, hydrogen peroxide and peracetic acid also work, and need to be in contact with spores for at least as long. But these materials can be corrosive and are not appropriate for homes and offices, though they can be used to decontaminate most laboratories. Spores can be boiled; the standard recommendation has been to keep the water at a rolling boil at least 10 minutes to kill spores of any pathogen. Steam also kills spores in from 1 to 10 minutes. In goat hair mills, the goat hair was treated at 170 degrees Fahrenheit for 15 minutes, but many spores retained their viability after this treatment. Moist heat works much better than dry heat. Fumigation can be performed with ethylene or propylene oxides, or paraformaldehyde gas. 8.I hope you can tell from this that I do not know a completely safe and effective way to perform decontamination. This needs to be an area of intensive investigation now. Dr. Alibek has suggested that methods used for decontamination in Sverdlovsk in 1979 (washing trees and houses, and paving dirt roads), may have re-aerosolized anthrax spores, and that this may have increased the number of cases of inhalation anthrax. 9.Dr. Ken Alibek suggested steam ironing letters before opening, which sounds like a good idea. Put a cloth between the iron and the letter. We need to know more about the temperature setting and how long the iron needs to be in contact with the letter. 10.The bottom line is that spores are odorless, tasteless, and invisible, individually. In a worst case scenario, up to one trillion spores (1,000,000,000,000) might be present in one gram of material. One gram can be contained easily within a one-ounce (28 gram) letter. It theoretically could contain a million lethal doses, if the majority of the spores were viable, of the right size, and dispersed easily without clumping. 11.What is a lethal dose of spores? The reason why you may read a variety of different estimates for this number is because a) there are no human-derived data, and b) there are a variety of factors that impact the answer. There are many animal experiments, and those results are surprising at times. It also depends on the virulence of the anthrax strain used, the amount of air you inhale (during exercise, you breathe in several times as much air as you do at rest), the % of viable spores, the distribution of size of spores, whether the spores easily separate from each other, and your own inherent immune system function. Thus the number might range from 10,000 spores to many millions. Animal tests of a sample from a letter should give us a rough idea of how virulent the potion is, and what a lethal dose might be. 12.Here are some animal data for lethal doses (LD50) of anthrax spores by subcutaneous injection and inhalation (from JM Barnes). This shows why there are so many cutaneous cases, compared to inhalation cases. Species # spores injected # spores inhaled Rabbit 600,000 100-1000 Guinea Pig 370,000 100-1000 Mouse 1,400,000 10-100 13.Another experiment in pigs: each of 50 pigs was fed from 10 million to 10 billion Ames strain spores (C Redmond et al.) Only 2 of the pigs died (4% of the total) and two others had anthrax isolated from blood, but survived. By 21 days after feeding the spores, the majority of pigs had developed antibodies to anthrax, indicating that they became infected and recovered. Humans, like pigs, are probably relatively resistant to anthrax, compared to many other species. 14.How do we know antiserum is likely to be protective? Mice, which are notoriously hard to protect against anthrax with vaccines, were given antiserum and then exposed to anthrax. The survival of mice given two different antisera was 80% at two weeks post exposure for both groups, while those given control sera had a 0% or 10% survival rate (RJ Beedham et al). 15.It remains very important to keep one's exposure to anthrax spores to a minimum, particularly if you work in a high risk industry, such as the postal service, UPS, Fedex, media or politics. Although I earlier advised against gas masks, I have come to believe there is a role for appropriate, well-fitted masks that have demonstrated efficacy in preventing inhalation of particles of the 0.5 to 5.0 micron size. My hope is that once environmental sensors are used widely, we will be able to discard masks. For now, if you feel there has been an exposure, or if you are trying to avoid exposure at a high risk occupation, HEPA dust masks (such as 3M Corp has sold for tuberculosis prophylaxis) may be useful. The more HEPA sheets in the mask, the better it will filter. These masks have not been tested for anthrax or other bioterrorism exposures, so 3M cannot market them for this purpose. However, such masks ought to keep out 95-99% of particles in the desired size range, and could be used for "high risk" activities such as opening mail. Gloves would also decrease one's exposure to spores, but must be discarded after use, or washed after use in order to reuse them. 16.Again, let me emphasize that a variety of soaps and detergents have been tested and were found to increase spore virulence by up to a factor of 16. That means the spores could be made 16 times as virulent, because soaps may make them easier to disperse as individual particles. For now, wash only in water first to remove spores; you can then use soap when the spores are down the drain. 17.There are many methodologies for identifying spores in the environment. I have collected a large number of articles on this subject, and will discuss what looks promising, and the differences between the methods, in a subsequent update. I continue to believe that PCR testing, because of its sensitivity and rapidity, should be the initial test done, with the understanding that some false positives will result, but no anthrax exposures will be missed, as long as sampling is adequate. I have spoken at length to Tom O'Brien of Tetracore, in Gaithersburg, MD. His company has some very promising PCR and immunoassays for anthrax that can be completed in under 12 hours, and can detect as few as 100 cfu (viable spores) per milliliter of material. 18.Diagnosing exposure in people is not that easy. Although obtaining nasal swabs is a simple procedure to perform, one study shows that the spores rapidly disappear from the nose after exposure, suggesting that swabs are only likely to be positive within 24 hours of contact. Thus sensitivity may be very low, and swabs will give you many false negative results. 19.Treatment is another question. I have suggested that many other antibiotics are as good or better than ciprofloxacin. Doxycycline, for instance, will also work for plague, tularemia and brucella, and effectiveness for all these other potential biowarfare pathogens has not been established for cipro. 20.The duration of antibiotic treatment needed remains uncertain. It is not clear if those currently being treated are being helped by antibiotics, or would not have become ill anyway. Antibody titers will tell if you successfully fought off anthrax. Although CDC Deputy Director David Fleming said that a four-fold rise in antibody titer is needed to confirm recent anthrax infection, this is not necessarily the case. Because anthrax is so rare, one positive antibody titer (by ELISA) should be adequate to make the diagnosis, as long as the ELISA test is accurate. 21.A pathologist called me today regarding an autopsy of a possible anthrax case. Autopsies can be a problem; in animals, when the animal is opened, spores form and are released. This could contaminate the autopsy suite. There may be temperatures in which this does not occur, but I don't know that for sure. I recommended instead, that blood, CSF and mediastinal fluid be sampled for the presence of the relatively unique-appearing gram positive fat rods of anthrax. This might save you from having to do a whole autopsy. 22.How to protect pets? The animal vaccine works quite well though it may require yearly boosters (there is little data on how frequently they must be given). 23.I guess my take home message is that, unlike other pathogens, which live in the environment for minutes to, at most, days, these spores last nearly forever. Contamination does not resolve with time, although if spores are kicked up inside buildings, they may disperse to less infectious levels. Outdoors, the spores tend to stick to the soil components and do not easily re-aerosolize. However, that may not be the case for indoor spore accumulations. First responders, affected workers, and others who may be in the vicinity of an anthrax event should behave as if there are invisible, potentially lethal spores everywhere: on surfaces, floors, your computer and desk, your person, walls and ceilings. This requires an entirely new mindset for dealing with infectious emergencies.


Source:
San Diego County
Dept of Health

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